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In vitro cellular experiments. A) Confocal images of CT26 cells incubated with DiD@CaCO3, DiD@4PI‐Zn, and DiD@AIM NPs for 8 h as indicated. B) Relative cell viability of CT26 cells treated with ...

The similar result was also observed in DNNPs formula (Fig. 1 f). Ascribing to the pH-responsive decomposition of CaCO 3, such DCaNPs showed more efficient DOX …

Calcium Carbonate / chemistry* Cell Line, Tumor Colorectal Neoplasms / drug therapy Colorectal Neoplasms / immunology Colorectal Neoplasms / pathology* Combined Modality Therapy Copper / chemistry* Humans

Co-incubation of cancer cells and fibroblasts, followed by nanoCaCO 3 treatment showed that the nanoparticles selectively inhibited the growth of the MDA- …

Therefore, lowering the lactate availability for Treg cells in the TME might synergistically support immune checkpoint inhibitor therapies as well as immune effector cell based therapeutic ...

Scheme illustrating the utilization of CaCO 3 @PLGA NPs to neutralize the acidic TME for reinforced cancer immunotherapies. Upon intravenous injection, CaCO 3 @PLGA NPs could effectively accumulate in the tumor site and neutralize tumor acidity to promote the reversal of tumor immunosuppression and the activation of exhausted CD8 …

Furthermore, the local generation of Mn 2+ in TME allows tumor-specific magnetic resonance imaging (MRI). More excitingly, the nanoregulator-reshaped TIME is effectively reserved due to the synergistic effect of hypoxia alleviation and MDSC PI3Kγ inhibition, leading to remarkable post-medication inhibition of tumor re-growth and …

Co-incubation of cancer cells and fibroblasts, followed by nanoCaCO 3 treatment showed that the nanoparticles selectively inhibited the growth of the MDA--231 cells and reduced cellular migration...

A CaCO3-based nanoplatform with sonodynamic and tumor microenvironment activated for combined in vitro cancer therapy A CaCO 3 -based nanoplatform with sonodynamic and tumor microenvironment activated for combined in vitro cancer therapy Transl Oncol. 2023 Sep 18;38:101771. doi: 10.1016/j.tranon.2023.101771. …

2204047 Cu/CaCO3@Ce6 nanoparticles (CCC NPs) with almost spherical morphology are constructed by directly doping Cu2+ during the facile one-pot synthetic …

Mn2+/Ir3+‐Doped and CaCO3‐Covered Prussian Blue Nanoparticles with Indocyanine Green Encapsulation for Tumor Microenvironment Modulation and Image‐Guided Synergistic Cancer Therapy - Ma - Advanced Healthcare Materials - …

Calcium Carbonate / chemistry* Cell Line, Tumor Colorectal Neoplasms / drug therapy Colorectal Neoplasms / immunology Colorectal Neoplasms / pathology* Combined …

Rational design of tumor microenvironment (TME)-activated nanocomposites provides an innovative strategy to construct responsive oncotherapy. In colorectal cancer (CRC), the specific physiological features are the overexpressed endogenous H 2 S and slightly acidic microenvironment. Here, a core–shell Cu 2 O@CaCO 3 nanostructure for …

Rationale: The synergism of new modalities alongside chemodynamic therapy into common chemotherapy has shown promising potential in clinical applications. This paper reports a tumor microenvironment-responsive nanosystem for chemodynamic/chemical synergistic therapy and magnetic resonance ima …

AM：Cu2O@CaCO3., ...

Due to the negative roles of tumor microenvironment (TME) in compromising therapeutic responses of various cancer therapies, it is expected that modulation of TME …

Abstract. The development of smart theranostic nanoplatforms has gained great interest in effective cancer treatment in facing the complex tumor microenvironment (TME), including weak acidity, hypoxia, and glutathione (GSH) overexpression.

The results showed that Ag-CaCO3 nanocomposites exhibited a maximum UV absorption peak at 430 nm, the surface-enhanced Raman spectroscopy (SERS) activity of Ag-CaCO3 nanocomposites was evaluated ...

1 3 Introduction Emerging evidences have shown that the tumor microenvi- ronment (TME) would foist a series of biological barriers to retard efective cancer treatment [1–5]. As a …

The acidity in the TME has been shown to block T cell activation and limit T cell glycolysis, negatively affecting the anti-tumor immune response 11. Acidity is a consequence of high rates of ...

Transarterial chemoembolization (TACE) is an important approach for the treatment of unresectable hepatocellular carcinoma (HCC). However, the lactic acid-induced acidic tumor microenvironment (TME) may reduce the therapeutic outcome of TACE. Herein, monodispersed gelatin microspheres loaded with ca …

Mn2+/Ir3+‐Doped and CaCO3‐Covered Prussian Blue Nanoparticles with Indocyanine Green Encapsulation for Tumor Microenvironment Modulation and …

Due to the negative roles of tumor microenvironment (TME) in compromising therapeutic responses of various cancer therapies, it is expected that modulation of TME may be able to enhance the therapeutic responses during cancer treatment. Herein, we develop a concise strategy to prepare pH-responsive ….

1. Introduction. It has been reported that nearly 90% of cancer patients die from tumor metastasis, and 30 ∼ 40% of malignant tumors including breast, head and neck, colorectal, urologic, gastrointestinal, breast, melanoma and gynecologic cancer suffer from lung metastasis [1].Notably, metastatic lung cancers together with primary ones have …

A CaCO3-based nanoplatform with sonodynamic and tumor microenvironment activated for combined in vitro cancer therapy A CaCO 3 -based …

Abstract. The development of smart theranostic nanoplatforms has gained great interest in effective cancer treatment in facing the complex tumor microenvironment (TME), …

Rational design of tumor microenvironment (TME)-activated nanocomposites provides an innovative strategy to construct responsive oncotherapy. In colorectal cancer (CRC), the specific physiological features are the overexpressed endogenous H 2 S and slightly acidic microenvironment. Here, a core-shell Cu 2 O@CaCO 3 nanostructure for CRC "turn-on" …

Compared to ACC@Cu 2 O-TPP (-) group, cells in ACC@Cu 2 O-TPP (+) group present obvious DCF fluorescence (green) after 24 h incubation under the …